Buy idebenone 500 mg capsules online each bottle contains 60 capsules.
Idebenone is a man-made product similar to coenzyme Q-10.
Idebenone The Benefits
- Protects the central nervous system in the case of ischaemic problems, ie, protects nerve cells from the effects of insufficient blood supply.
- Protects neurons from excitotoxicity caused by the presence of excessive levels of two excitatory neurotransmitters in the brain – glutamic acid or glutamate, and aspartic acid.
- Improves cholinergic activity which is involved in memory function and learning.
- Increases production of nerve growth factor which may stimulate cognitive capacity.
- In addition to these actions, idebenone may also offer certain advantages over coenzyme Q10 in that it can potentially withstand hypoxic situations, ie, it does not auto-oxidise in the absence of sufficient oxygen. Idebenone may therefore be a more potent and resistant alternative to coenzyme Q10.
- Like coenzyme Q10, idebenone has attracted scientific interest for its potential therapeutic applications. It is being investigated primarily as a possible treatment for certain types of myopathy, neuromuscular diseases characterised by degeneration of muscle cells or muscle fibres as they’re more commonly known.
- It may, in particular, help combat cell degeneration. Preliminary findings have been positive for the treatment of Duchenne muscular dystrophy, a severe form of myopathy. Further studies are underway to confirm these findings and pave the way for the development of myopathy treatments.
Uses For IDEBENONE 500mg Capsules
Idebenone is a potent antioxidant and inhibitor of lipid peroxidation which has been
shown to protect cell membranes and mitochondria from oxidative damage. Idebenone
also stimulates mitochondrial electron
Idebenone is used for Alzheimer’s disease, liver disease, and heart disease; as well as a number of inherited disorders including Leber’s disease (an eye condition), mitochondrial encephalomyopathies (nerve and muscle disorders), and Friedreich’s ataxia (a nervous system disorder that worsens over time, producing gait and speech problems, and eventually leading toward heart disease and diabetes).
Idebenone is a potent antioxidant and inhibitor of lipid peroxidation which has been
shown to protect cell membranes and mitochondria from oxidative damage. Idebenone
also stimulates mitochondrial electron flux and cellular energy production by bypassing
the complex I defect and stimulating an alternative pathway through complex III.
How does idebenone work
Idebenone seems to have antioxidant activity, and appears to protect a wide variety of cells from oxidative damage.
Rate and extent of absorption of idebenone
Peak plasma concentrations of idebenone occur about 1 to 4 hours after oral
administration. Absolute bioavailability has not been determined.
Metabolism and distribution of idebenone
Idebenone is extensively metabolised in the liver, predominantly by oxidative shortening
of the side chain and by conjugation (either glucuronidation or sulphation). Approximately
56 to 78% of an oral dose is recovered as metabolites in urine compared to less than 1%
as unchanged drug. Plasma concentrations of idebenone 500 mg are much lower than the
concentrations of its metabolites at all times after oral dosing, indicating that the first-pass
effect is extensive.
Primary pharmacology
Weakness of respiratory muscles leading to respiratory insufficiency is a key pathological
feature associated with DMD. Duchenne muscular dystrophy is characterised by cell
membrane fragility and intracellular Ca2+ dysregulation secondary to the disease-causing
absence of the protein, dystrophin. This muscle cell membrane damage causes functional
aberrations in mitochondrial energy transduction and increased production of cell damaging reactive oxygen species (ROS). Mouse myoblasts from mdx mice (engineered to have a point mutation in the dystrophin gene and exhibiting a mild DMD phenotype)
Idebenone 500 mg demonstrate abnormalities in several mitochondrial functions including decreased basal
oxygen consumption and levels of Complex I, III and V and increased mitochondrial
membrane potential and ROS production. The cellular pathology at the mitochondrial level
in dystrophic muscle cells manifests in multiple deficiencies of various metabolic
pathways to culminate in adenosine triphosphate (ATP) insufficiency and excessive ROS
formation.
Upon entering the cell, idebenone is reduced by the cytoplasmic enzyme NADH-quinone
oxidoreductase 1 (NQO1) and the resulting reduced form enters the mitochondria where
it is re-oxidised by complex III, bypassing complex I-dependent ATP synthesis. Idebenone
can therefore restore mitochondrial function in the presence of complex I dysfunction.
Idebenone also inhibits mitochondrial ROS formation. It is proposed that idebenone
prevents muscle deterioration in DMD via its ability to increase cellular energy
production, reduce ROS formation and protect from cell-damaging oxidative stress.
Idebenone restored mitochondrial function in the presence of Complex I inhibition in a
mouse model of Leber’s hereditary optic neuropathy where it effectively prevented retinal
ganglion cell death and decreased retinal thickness induced by rotenone (a complex I
inhibitor). Idebenone improved cardiac parameters after induction of ischemia by
mediating a more rapid recovery of pulse rate and coronary blood flow and preventing a
reduction in cardiac glycogen in perfused rat hearts ex vivo. Idebenone also prevented
ischemia induced S-T segment increases in electrocardiograms (ECG) (a hallmark of
myocardial infarction) in dogs.
In mdx mice, idebenone prevented deleterious changes in
cardiac physiology (such as reductions in heart rate, end-diastolic pressure and
isovolumetric relaxation during diastole) and muscular parameters (including impaired
running distance and increased variability in quadriceps, but not diaphragm, striated
muscle fibre diameter). Idebenone also decreased mortality in a dobutamine stress test
caused by left ventricular dilatation, reduced the likelihood of cardiac fibrosis
development and reduced cardiac inflammation and serum troponin levels.
Idebenone Use
Each Idebenone 500 mg capsules should be administered with food because food increases the bioavailability of
idebenone.
Each capsules maybe taken once or twice daily or under the advice of your health care professional.