Anti Aging Supplement

For years we have been looking at a large number of anti aging supplements. Many of these are just over priced or just don’t deliver as they are packed full of fillers that offer nothing in the way of anti aging or any added health benefit.

Wanting to offer a low dose 45mg Idebenone capsule without fillers but we wanted to offer great value for money so we decided to come up with a great products that could do away with many anti aging supplements.

This custom formulation is the very same formula we use daily to reduce Oxidative Stress, Inflammation, DNA damage and increase energy and mood. This can be used as a general supplement and may also be used with other vitamin and mineral supplements for greater benefits.

Best used as a Anti-aging and antioxidant supplement taken with food daily.

Each capsule contains the following:

• Idebenone 45mg
• Curcumin Extract 95%
• Quercetin
• Resveratrol
• Green Tea Extract EGCG
• L-Taurine
• Ashwagandha Extract
• Piperine Extract 95%
• Asc2P
• L. rhamnosus Lr-32
• B. animalis ssp. lactis HN019
• B. lactis BI-04
• L. paracasei Lpc-37
• L. plantarum Lp-115
• L. casei Lc-11
• S. thermophilus St-21
• B. breve Bb-18
• B. longum BI-05
• L. plantarum CECT 7527
• L. plantarum CECT 7528
• L. plantarum CECT 7529
• B. infantis Bi-26
• L. delbrueckii ssp. bulgaricus Lb-87
• L. reuteri 1E1
• Lithium Orotate

Dose: Take one capsule 1 to 3 times daily with food.

Packaging: 60 capsules.

Each Idebenone 45mg capsules should be administered with food because food increases the bioavailability of
idebenone.

Idebenone

Idebenone’s antioxidant potency means it protects against oxidative stress, oxidation and free radical damage. This beneficial effect may help slow down cognitive decline by protecting the central nervous system.

• Powerful antioxidant effects.
• Protects the body against the oxidative stress responsible for cellular ageing.
• May help slow down cognitive decline by protecting the central nervous system.

Piperine 

Piperine potentiates the bioavailability of many supplements, but it is curcumin supplements known for their powerful anti-inflammatory effects, that most benefit from being combined with Piperine.

Curcumin’s bioavailability is actually very low because it is quickly metabolised in the liver. Taking curcumin will only produce a very slight increase in plasma concentrations. However, taking piperine at the same time produces a clear increase in curcumin levels, in the region of 2000%, within around 30 minutes of ingestion.

Can increase absorption of selenium and vitamin C by up to 42% and 50% respectively. Below are just some of the many micronutrients where absorption can be improved by piperine:

• Curcumin ; Iron ; Resveratrol ;Selenium; Vitamin B6;β-Carotene; Extract of Boswellia serrata; Extract of Ginkgo biloba, and Proteins in general.

Peperine has been included in this formulation to enhance the bioavailability of Curcumin, Quercetin and Resveratrol.

Curcumin Extract

Curcumin is a yellowish pigment found in turmeric, a plant in the ginger family.

In studies, curcumin intake has been shown to extend lifespan of diverse species, from roundworms to mice. In a study of fruit flies, for example, it increased the average lifespan by 26%.

In addition, research suggests it can help in the management of many conditions including metabolic syndrome, elevated lipids, arthritis, and more.

A number of studies have found that curcumin supplementation led to improvements in cognition and memory. 

Protecting Telomeres

Every strand of DNA in our body has protective end caps, called telomeres, that help maintain the stability and function of the genetic material.

As we age, these telomeres shorten. When they are too short, the cell becomes dysfunctional or die. Shortened telomeres limit regeneration and stem cell function.

Telomerase is an enzyme that builds up the length of existing telomeres.

Curcumin has been shown in preclinical studies to give a boost to this anti-aging enzyme. It can enhance the expression and activity of telomerase, increasing the health and life of cells. 

There are many more anti-aging actions of curcumin. Among other benefits, curcumin:

• Acts as a potent free-radical scavenger, helping to prevent the oxidative stress that accompanies most age-related chronic disease,
• Triggers production of the body’s own antioxidant enzymes, 
• Reduces chronic inflammation, another driver of aging and age-related disease,
• Supports healthy mitochondrial function, and
• Activates autophagy, cellular “house-keeping,” to rejuvenate cells and keep them functioning optimally.

Quercetin

Quercetin is a flavonol from the family of flavonoids, the phenolic compounds responsible for the colour of flowers, fruits and vegetables. The best dietary sources of quercetin are tea, apples, and red and white onions, followed by red wine, broccoli, citrus fruit and red fruits in general.

An excellent antioxidant. Like all flavonoids, quercetin strengthens the walls of capillaries and other small blood vessels by reducing their permeability, and has antioxidant properties. It therefore helps to combat ever-present oxidative stress.

A natural antihistamine. Quercetin plays a part in relieving allergies, seasonal or otherwise: asthma, sneezing, itching, hay fever, eczema, urticaria and allergic rhinitis. In fact, a number of studies have shown that quercetin is effective at stabilising membranes of the mastocytes responsible for releasing histamine. By reducing the degranulation of these cells, it directly addresses the source of the allergic reaction and its associated symptoms.

Anti-inflammatory properties. Taken at a daily dose of 1000mg, quercetin confers anti-inflammatory benefits that last throughout the day. This anti-inflammatory potency comes primarily from quercetin’s ability to inhibit the NF-kappaB pathway, a protein that plays a key role in controlling expression of the genes encoding proinflammatory cytokines. Its clearest effects are on chronic inflammation of the prostate and urinary tract (interstitial cystitis). Prostatitis, which can be caused by a bacterial infection, can sometimes become chronic: in a double-blind study, it was noted that taking quercetin can significantly relieve symptoms of chronic prostate inflammation. Quercetin has also been shown to provide effective relief of arthritic pain, with one report stating that when taken at a dose of at least 750mg a day, it may work within just two or three days.

Effective protection of the cardiovascular system. Human studies conducted in Finland have demonstrated the benefits of quercetin supplementation in preventing coronary problems and in reducing the incidence of stroke. In animals, in vitro studies showed a protective effect against cardiovascular diseases and clinical studies have also confirmed its hypotensive effect. In addition, it reduced LDL-cholesterol levels in overweight subjects and inhibited platelet aggregation, a mechanism involved in the development of atherosclerosis.

An excellent anti-ageing compound. In Russia, quercetin is considered to be a major anti-ageing aid, referred to the ‘Russian Rejuvenator’. It may indeed improve longevity by on the one hand, reducing the impact of certain chronic diseases, and on the other, having a direct effect on life expectancy, at least, according to several studies, in experimental organisms. One Portuguese study concluded that the life expectancy of yeast cells in culture increased by 60%, while a team of German biologists showed that feeding C. elegans worms a diet rich in flavonoids, including quercetin, may improve their overall health and longevity, most probably by activating four specific genes. Other scientists have also suggested it might mimic certain effects of calorie restriction on life expectancy, as does resveratrol.

Invaluable for sportspeople. Levels of oxidative stress, inflammation and immune dysfunction all increase in athletes and sportspeople engaging in prolonged physical activity. Taking quercetin helps to reduce the negative effects of sustained exercise by reducing markers of inflammation and oxidative stress. What’s more, double-blind studies on mountain bikers cycling a distance of around 30 kilometres showed that supplementing with quercetin for a period of three weeks helped improve their performance by around 3.1%, a considerable increase given that such results are normally only obtained by using performance-enhancing drugs or in athletes training at high altitudes. Another study, which examined the effects of 14 days’ supplementation with 1000mg quercetin on time trials performed on a treadmill, showed an improvement in performance of 2.9%.

Resveratrol

Resveratrol is a protective compound produced by red grapes (and certain other plants) as a defence against parasites.

Many studies have demonstrated that resveratrol is a powerful antioxidant and that it protects human health through a number of mechanisms. Indeed, research attributes much of the health protection conferred by the famous French paradox’ to resveratrol.

Cardiovascular benefits

• The World Health Organisation suggests that resveratrol single-handedly reduces cardiovascular risk by 40%.
• Resveratrol is more effective than vitamin E, protecting against a wider range of free radicals to prevent oxidation of low-density lipoprotein (LDL).
• It inhibits platelet aggregation by blocking the action of thrombin and several other aggregating factors.
• It promotes production of nitric oxide which relaxes and dilates the arteries.
• It reduces blood triglyceride and cholesterol levels as well as the intrinsic hypertensive agent endothelin-1.

Antioxidant properties

Preliminary studies suggest that resveratrol – administered singly, and in combination with other antioxidants – protects the brain against oxidative stress. Oxidative stress is known to play a major role in most neurodegenerative diseases.

A Chinese study has recently shown that, when injected immediately after injury, resveratrol is as effective as the drug prednisone at protecting against inflammation of the spinal cord, but with additional benefit of antioxidant protection. A study of rats pre-supplemented with resveratrol for 21 days has shown that it improves the prognosis, and reduces the permanent effects of stroke.

According to a study at Harvard Medical School, resveratrol activates a longevity gene in certain strains of yeast and extends life expectancy by 70%. It works in the same way as calorie restriction (the only scientifically-proven way of increasing longevity) by activating SIR genes. Research to date has been restricted to yeasts, flies and nematodes but it’s worth noting that humans also possess these genes.

Green Tea Extract EGCG

Epigallocatechin-gallate (EGCg), has significant antioxidant capacity because of its high content in the most powerful of the catechins, EGCg – it is 20 times more potent than vitamin E. EGCg neutralizes reactive oxygen species and free radicals and as it easily crosses the blood-brain barrier, it helps protect the brain from oxidative stress. Taking a green tea extract standardized in EGCg produces a faster increase in antioxidant levels in the blood than drinking green tea, with none of the side-effects of theine. This ability to neutralize age-related free radicals makes Green Tea Extract EGCg a key anti-ageing supplement for ensuring antioxidant protection.

Studies conducted on green tea over the last few years have provided mounting evidence of the health benefits of its polyphenols, such as:

• Potent antioxidant, anti-bacterial and anti-cariogenic effects.
• Protection of the kidneys.
• Thermogenic properties, promoting effective weight control.
• Regulating blood sugar and lipid levels.
• Important role in longevity.

Green tea extracts standardized in polyphenols, particularly EGCg, are now also recognized for their ability to lengthen telomeres. According to a large-scale Chinese study conducted by the University of Hong Kong involving over 2000 participants aged 65 or over, consuming at least 700ml of green tea a day was associated with an average increase in telomere length of over 46%, corresponding to a five-year extension in lifespan, particularly in men.

Its most important characteristic, however, was highlighted recently in a series of studies conducted at the Charité University of Berlin. This cell-experimental and animal research showed that EGCg has a neuro-protective effect over and above its antioxidant effects, related to the expression of genes regulating cell survival or programmed cell death (apoptosis) as well as modulation of mitochondrial function. It seems EGCg causes an induction of alpha-secretase as well as other enzymatic mechanisms and prevents the aggregation of beta-amyloid to toxic oligomers. Study author Dr Paul Friedemann and his fellow researchers thus consider EGCg to be a promising substance in the prevention of Alzheimer’s disease and its development.

L-Taurine

Taurine is present at significant levels in the brain and muscles where it plays an important role in a number of biological processes. In cardiac muscle, it is primarily involved in cardiac contractility. It is also involved in growth processes and is essential for the maturation of the nervous system. In general terms, it helps protect vital functions and as such, may be involved in the antioxidant activity of white blood cells, fighting cell damage. In addition to these protective effects, it may also be involved in processes such as the digestion of fats and sperm motility.

• It increases the action of insulin, improving glucose tolerance, and acting as an antioxidant.
• It is vital for the proper function of the minerals potassium, calcium, magnesium, and sodium.
• Taurine regulates heart rhythm, cardiac contraction, blood pressure, and platelet aggregation, and regulates the excitability of neurons.
• It detoxifies liver cells of various toxins.
• It helps form bile acids and maintains cell membrane stability.
• It reduces the synthesis of lipids and cholesterol that are associated with atherosclerosis.
• Strong epidemiological evidence suggests that certain groups with the longest life spans consume higher amounts of taurine than those of us in the rest of the world.
• Taurine is critical for normal brain function.
• It helps maintain healthy mitochondrial energy supply, which is typically diminished with advancing age.
• It spurs the growth of new brain cells, even in old age.
• Maintaining adequate taurine levels may help reduce age-related threats to cognitive function, such as neurotoxins, oxidative stress, and inflammation.
• In preclinical studies, taurine has been shown to support brain function while shielding against dementia-associated changes and various forms of brain injury.

Ashwagandha Extract

Ashwagandha (Withania somnifera). In Ayurvedic medicine, ashwagandha is considered a Rasayana – a tonic for restoring and maintaining health and longevity.

Ashwaganda is a plant native to the dry regions of India such as Rajasthan and Gujarat, but also grows in Nepal, China and Yemen. Sometimes known as Indian ginseng, the ashwagandha plant has been used in traditional Indian medicine for thousands of years as an Ayurvedic tonic and revitaliser. Its reputation comes from its many medicinal properties: it is thought to have anxiolytic, hypotensive, pain-relief and antioxidant effects.

This energising plant is traditionally used to treat problems related to ageing, impotence and mental fatigue.Offered as a natural anti-stress remedy to help soothe and relax, ashwagandha is also used to combat insomnia and anxiety. With its many benefits and anti-stress effects, ashwagandha is classified as an adaptogen plant. These atypical plants have the particular feature of increasing the body’s ability to adapt to different stressful situations. In other words, they tend to regularise various metabolic functions.However, not only are there differences in how these adaptogen plants behave, but their effects can vary from one individual to another. This is the case with ashwagandha which tends to have a particular effect on brain function and the immune system.

It is ashwagandha’s steroidal lactone content, particularly withanolides, which are responsible for this medicinal plant’s stimulant and beneficial effects.

• Of these withanolides, withaferin A may be the plant’s most powerful active principle.
• This molecule appears to have a number of beneficial effects on the body’s cells: anti-inflammatory, cardio-protective, neuroprotective, immune-suppressant and anti-tumour.
• While additional studies are underway to further explore its mechanisms of action, withaferin A could well offer significant therapeutic potential, both in terms of the prevention and treatment of certain diseases.
• Our ashwagandha extract contains standardised to contain more than 5% withanolides.

telomerase-activity

Ashwagandha root extract powder, at a concentration of only 10 µg to 50 µg, increased telomerase activity by 45% upon 72 hours of exposure.

Recent research shows “Ashwagandha root extract is able to enhance telomerase activity,” and suggest it should be evaluated under various adult onset disease conditions for its holistic protective effect.

Asc2P

Asc2P also know as Magnesium ascorbyl phosphate (L-Ascorbic acid 2-phosphate magnesium) is a very stable and powerful form of vitamin C.

• A stable and potent form of vitamin C that can penetrate cells, and that maintains telomere length
• Has a key role in maintaining the immune system, boosting the body’s natural defences.
• 20 times more powerful than the classic ascorbic acid form of vitamin C.
• Recognised for its antioxidant effects and often described as an ‘anti-fatigue vitamin’.

Asc2P is a quite specific form which is around 20 times more powerful than the classic ascorbic acid form of vitamin C. The beneficial effects of vitamin C have been scientifically shown to help protect the body against cellular ageing and prevent the development of certain age-related diseases. Vitamin C is thus considered by some to be an anti-ageing vitamin. In addition to its natural antioxidant activity, vitamin C is involved in numerous metabolic reactions. Multiple scientific studies have confirmed how important it is to the human body, with the following functions among the most widely-studied:

• Has a key role in maintaining the immune system, boosting the body’s natural defences.
• Contributes to the production of red blood cells, responsible for oxygenating the body.
• Participates in the formation of collagen, a protein involved in the mechanical resistance of tissues.
• Structures and maintains tissues such as the skin, artery walls, ligaments and bones.
• Contributes to the synthesis of neurotransmitters such as noradrenalin, involved in the transmission of nerve impulses.
• Promotes the body’s absorption of plant-sourced iron.
• Produces carnitine, a molecule involved in the transport and use of fatty acids by the mitochondria for providing energy.

L. plantarum CECT 7527 L. plantarum CECT 7528 L. plantarum CECT 7529

Three Lactobacillus plantarum strains (CECT 7527, 7528 and 7529) were selected as potential probiotics to reduce cholesterol levels after conducting several in vitro tests for demonstrating the functionalities of the strains according to international guidelines.

Results: The three strains showed a high ability to survive under gastrointestinal tract conditions and to adhere to intestinal cells. Regarding lipid metabolism, the strains showed a great production of bile salt hydrolase, especially when combined. Moreover, the strains assimilated cholesterol directly from the medium. Part of the cholesterol present in the medium was removed via binding onto the bacterial cellular surface. Finally, the three strains, especially CECT 7529, produce large quantities of propionic and butyric acids.

Conclusion: Combined, these characteristics suggest that these strains could be excellent candidates for reducing high blood cholesterol levels.

L. rhamnosus Lr-32

Lactobacillus rhamnosus Lr-32 (DIARRHEA & CONSTIPATION) – promotes general GI health and function especially to support occasional diarrhea and constipation after probiotic treatment.

B. animalis ssp. lactis HN019

B. lactis HN019 was shown to support maintaining the healthy/normal intestinal microbiota against aging process and by competing and excluding harmful pathogens, both at taxonomical and functional levels. In addition, further evidence for intestinal microbiota support can be found from combination products containing B. lactis HN019.

Research supports the hypothesis that B. lactis HN019™ has a beneficial role in maintaining intestinal barrier function during gastrointestinal infections by competing and excluding potential pathogens via different mechanisms; maintaining normal tight junction function in vitro; and regulating host immune defense toward pathogens in both in vitro and human studies. This has been observed to lead to reduced incidence of diarrhea. Interestingly, B. lactis HN019™ also supports normal physiological function in immunosenescent elderly and competes and excludes potential pathogens. Furthermore, B. lactis HN019™ reduced intestinal transit time and increased bowel movement frequency in functional constipation, potentially by modulating gut–brain–microbiota axis, mainly via serotonin signaling pathway, through short chain fatty acids derived from microbial fermentation. B. lactis HN019™ is thus a probiotic that can contribute to relieving gut dysmotility related disorders.

L. paracasei Lpc-37

Lacticaseibacillus paracasei Lpc-37 improves psychological and physiological markers of stress and anxiety in healthy adults: a randomized, double-blind, placebo-controlled and parallel clinical trial.

L. plantarum Lp-115

Lactobacillus plantarum has been used in human clinical trials to promote beneficial effects in the immune system, to alleviate intestinal disorders, and to reduce the risk of cardiovascular disease.

•Immune modulation

• L. plantarum Lp-115 may improve specific immune response, as demonstrated in a human clinical study

• L. plantarum Lp-115 may have an influence on immune regulation, as demonstrated through balancing of IL-10/IL-12 in vitro

• L. plantarum Lp-115 may decrease important cardiovascular risk factors, such as glucose and homocysteine

• L. plantarum Lp-115 may reduce risk for postoperative infections

L. casei Lc-11

The immune-regulating properties of Lactobacillus casei have been reported in several studies. L. casei has been shown to regulate inflammatory pathways and reduce oxidative stress, indicating an antioxidant effect. L. casei has also been shown to support immune function by increasing natural killer (NK) cell activity and maintain normal inflammatory balance.

S. thermophilus St-21

Streptococcus thermophilus also produces antibiotic chemicals to prevent infection from infections like pneumonia, C. difficile and can help prevent ulcers.

• improve digestion
  • reduce antibiotic associated diarrhea
  • decrease ulcerative colitis symptoms
  • decrease leaky gut symptoms
  • improve lactose digestion
  • decrease IBS symptoms
  • decrease acute diarrhea
• enhance immunity
  • prevent & fight upper respiratory infections (eg. pneumonia)
  • prevent ulcers caused by H. pylori
  • decrease AIDS symptoms
  • fight Clostridium difficile
  • increase immunity
• additional health benefits
  • improve non-breast-fed infant probiotic flora
  • reduce symptoms of atopic dermatitis
  • prevent bacterial vaginosis infections
  • decrease chance of kidney stones
  • increase HDL (good cholesterol)
  • increase anti-tumor activity
  • decrease baby colic

B. longum BI-05

Bifidobacterium longum. Bl-05 may inhibit pathogens and protect the GI tract by interacting with the intestinal mucosa and modulating the immune system.

A noteworthy two-week murine study found that daily feeding probiotic cheese fortified with Bl-05 resulted in more than a 100% increase in HDL (“good”) cholesterol and a 50% decrease in total blood triglycerides. Therefore, Bl-05 may favorably alter biomarkers associated with cardiovascular function. 

B. infantis Bi-26

According to a probiotic research database, B. infantis can help with GI issues.

In addition, B. infantis may also help with mental health and mood.  Animal studies conducted by Desbonnet in 2008 and 2010 suggest that the use of B. infantis is effective in the normalization of the immune system.

• Cooperates with other gut-microbiome bacteria to harvest energy from non-digestible nutrients, ultimately leading to the creation of butyrate
• Occupies space in the gut microbiome that potentially harmful microbes would otherwise fill

L. delbrueckii ssp. bulgaricus Lb-87

Lactobacillus delbrueckii subsp. bulgaricus, Lb-87, is fairly resistant to acidic conditions and has a very good survival rate in the presence of bile . It also has a good adhesion to human intestinal mucus in vitro, which gives it the potential to be more effective in protecting the gut against enteric pathogens. It does this by limiting the pathogen’s ability to colonize the intestine.

L. reuteri 1E1

Lactobacillus reuteri is a species of probiotic bacteria. It may provide some benefits for cholesterol levels, reducing H. pylori levels (the pathogenic bacterium which contributes to ulcers), female urinary tract and vaginal health, and infant gastrointestinal health.

Lithium Orotate

• Lithium is a trace mineral found in the earth’s crust, and therefore in some, but not all, drinking water.
• Studies suggest that GSK-3 inhibition is also largely responsible for lithium’s ability to protect brain function and extend lifespan.
• Even at low doses, lithium intake has been associated with decreased all-cause mortality in humans and increased longevity in roundworms.
• Lithium plays a critical role, from slowing the aging process to protecting the brain and improving mental health, and more.
• Small daily doses of lithium may be an effective way to slow aging and cognitive decline and extend life.